Pain Neuroscience Education
Moderate effects on pain catastrophizing, disability, and pain intensity when combined with other interventions. Most effective as adjunct, not standalone.
Pain education reduces catastrophizing and fear-avoidance; functional outcomes moderate when combined with movement.
Applicable to virtually any patient with pain; cross-cutting utility across outpatient ortho, neuro, and chronic care.
Billed as therapeutic education; supports patient education CPT codes; no dedicated pain neuroscience billing code.
1-2 day workshop; low-moderate cost; multiple providers available; very accessible.
Growing employer interest; increasingly listed in chronic pain, outpatient ortho, and behavioral health rehab postings.
Patients report relief from understanding their pain; reduces helplessness and catastrophizing.
Chronic pain patients pay cash, but PNE alone isn't a service consumers shop for; it's an adjunct.
Limited premium pricing; PNE is increasingly considered standard care, not a luxury offering.
Becoming commoditized; many PTs now claim PNE familiarity, eroding differentiation.
Protocolizable and teachable to associates; works well as a clinic-wide approach.
Public recognition is low; few patients seek out a 'PNE provider' by name.
Short courses (often 1-2 days), inexpensive; very efficient to acquire.
Highly regarded in academic pain science circles; signals current evidence-based practice.
Strong and rapidly growing literature with prominent academic figures (Louw, Moseley).
Core content in modern DPT pain curricula; very high curricular utility.
Substantial RCT and systematic review evidence, though effect sizes are modest as standalone treatment.
Increasingly preferred for faculty with pain or chronic-condition focus.
Short, inexpensive training with strong academic legitimacy; excellent ROI.
- 01DOI ↗The effectiveness of pain neuroscience education in people with chronic non-specific low back pain: An umbrella review with meta-analysisJ. G. Cancela; O. C. Vázquez; S. N. Ledesma; L. Pruimboom · Ann Phys Rehabil Med · 2025Meta-analysisdoi:10.1016/j.rehab.2025.102020
- 02DOI ↗Workplace-based physiotherapy of elderly-care workers with non-specific chronic neck pain: a randomized controlled trialM. Cardero-Durán; L. Espejo-Antúnez; C. Fernández-Morales; M. Albornoz-Cabello; J. Rodríguez-Mansilla · J Occup Environ Med · 2025RCTdoi:10.1097/jom.0000000000003566
- 03DOI ↗Home-Based Transcranial Direct Current Stimulation vs Placebo for Fibromyalgia: A Randomized Clinical TrialW. Caumo; B. R. Franca; R. Orzechowski; G. Bueno; A. França; J. V. dos Santos da Silva; P. R. S. Sanches; D. P. Da Silva Jr; I. L. S. Torres; V. N. Hirakata; K. Pacheco-Barrio; F. Fregni · JAMA Network Open · 2025RCTdoi:10.1001/jamanetworkopen.2025.14262
- 04DOI ↗Social Media-Based Pain Neuroscience Education for Temporomandibular Joint Disorder: A Randomized Controlled TrialY. K. Cho; Y. L. Jung; A. Im; S. J. Hong; K. Kim · Pain Manag Nurs · 2025RCTdoi:10.1016/j.pmn.2024.12.010
- 05DOI ↗Effectiveness of Adding a Pain Neuroscience Education Program to a Multimodal Physiotherapy Intervention in Patients with Chronic Shoulder Pain: A Randomized Clinical TrialJ. A. Delgado-Gil; E. Prado-Robles; M. N. Muñoz-Alcaraz; J. Seco-Calvo · Brain Sci · 2025RCTdoi:10.3390/brainsci15020125
- 06DOI ↗The Effects of Pain Neuroscience Education Plus Conventional Physical Therapy on Pain and Quality of Life in Adults with Chronic Nonspecific Neck Pain and Central SensitizationF. Derisfard; F. Soleimani; M. Saadat; M. Saeidi; H. K. Mohammadi · Journal of Rehabilitation Sciences & Research · 2025Otherdoi:10.30476/jrsr.2024.96622.1317
- 07DOI ↗Pain Neuroscience Education Versus Biomedical Pain Education with Exercise in Primary Dysmenorrhea: A Randomized Controlled TrialB. N. Erol; C. Gürşen; S. Mümüşoğlu; S. Özgül · Healthcare (2227-9032) · 2025RCTdoi:10.3390/healthcare13161954
- 08DOI ↗The Effect Of Pain Neuroscience Education And Blended Exercises On Pain, Functional And Psychological Factors In Knee Oa: A Single-blind RCT: 3043...American College of Sports Medicine (ACSM) Annual Meeting, May 27-30, 2025, Atlanta, GeorgiaZ. Gholami; S. T. Faezi; A. Letafatkar; E. Madreseh · Medicine & Science in Sports & Exercise · 2025RCTdoi:10.1249/01.mss.0001159400.96403.51
- 09DOI ↗Additional effects of therapeutic exercise and education on manual therapy for chronic temporomandibular disorders treatment: a randomized clinical trialC. Justribó-Manion; J. Mesa-Jiménez; J. Bara-Casaus; J.-C. Zuil-Escobar; K. Wachowska; G. Álvarez-Bustins · Taylor & Francis Ltd · 2025RCTdoi:10.1080/09593985.2024.2316305
- 10DOI ↗Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled TrialJ. B. Larsen; S. T. Skou; M. Laursen; N. H. Bruun; P. Madeleine; L. Arendt-Nielsen · Eur J Pain · 2025RCTdoi:10.1002/ejp.70064
- 11DOI ↗Pain Science Education, Stress Management, and Cognition-Targeted Exercise Therapy in Chronic Whiplash Disorders: A Randomized Clinical TrialA. Malfliet; D. Lenoir; C. Murillo; E. Huysmans; B. Cagnie; M. Meeus; W. Willaert; K. Ickmans; L. Danneels; J. Bontinck; J. Nijs; I. Coppieters · JAMA Network Open · 2025RCTdoi:10.1001/jamanetworkopen.2025.26674
- 12DOI ↗Effectiveness of pain neuroscience education, motivational interviewing and cognition targeted exercise therapy in patients with chronic neck pain: protocol for a multicentre randomised controlled trial (the COGMO-AP study)D. Morales Tejera; J. Nijs; A. Malfliet; M. A. Prieto Aldana; M. I. Gallardo Vidal; E. Polentinos Castro; M. T. Linares Fernández; J. Fernández-Carnero · BMJ Open · 2025RCTdoi:10.1136/bmjopen-2024-087788
- 13DOI ↗It is something you live with, like an organ in your body" a qualitative study on the lived experiences of people suffering from chronic low back pain in Lebanon"C. Najem; A. J. Wijma; M. Meeus; B. Cagnie; F. Ayoubi; J. Van Oosterwijck; K. De Meulemeester; C. P. Van Wilgen · Disability & Rehabilitation · 2025Qualitativedoi:10.1080/09638288.2024.2384620
- 14DOI ↗Acceptability of multimodal and multidisciplinary group-based program for chronic low back pain: a qualitative studyM. Ochandorena-Acha; A. Dalmau-Roig; C. Dürsteler; F. Vilchez-Oya; A. Ferrer; I. Martin-Villalba; A. Obach; M. Terradas-Monllor · Taylor & Francis Ltd · 2025Qualitativedoi:10.1080/09593985.2024.2377343
- 15DOI ↗Effectiveness of pain neuroscience education among adults with chronic neck pain. Systematic reviewI. Palahí-Calsina; J. Jubany; L. Sordo; S. Lorente; A. Espelt; O. Borao · European Journal of Physiotherapy · 2025Systematic reviewdoi:10.1080/21679169.2024.2365694
- 16DOI ↗Pain Neuroscience Education and Resistance Training in Women With Fibromyalgia: A Randomized Control Pilot StudyJ. Rodríguez-Domínguez Á; M. Rebollo-Salas; R. Chillón-Martínez; M. Cardellat-González; L. Blanco-Heras; J. J. Jiménez-Rejano · Pain Res Manag · 2025RCTdoi:10.1155/prm/7550108
- 17DOI ↗Effectiveness of Pain Neuroscience Education in Physical Therapy: A Systematic Review and Meta-AnalysisA. Sánchez-Robalino; H. Sinchi-Sinchi; A. Ramírez · Brain Sci · 2025Meta-analysisdoi:10.3390/brainsci15060658
- 18DOI ↗The efficacy of pain neuroscience education in patients after total knee arthroplasty: a single blind randomized controlled trialA. Tayfur; F. Özyurt; M. Kodak; M. F. Çakmak; G. Özsoy; B. Çiğdem Karaçay; İ. Özsoy; H. Basat; C. Karartı · Physiother Theory Pract · 2025RCTdoi:10.1080/09593985.2025.2526025
- 19DOI ↗Preoperative Home-Based Multimodal Physiotherapy in Patients Scheduled for a Knee Arthroplasty Who Catastrophize About Their Pain: A Randomized Controlled TrialM. Terradas-Monllor; H. Beltran-Alacreu; M. Ochandorena-Acha; E. Garcia-Oltra; F. Aliaga-Orduña; J. Hernández-Hermoso · J Clin Med · 2025RCTdoi:10.3390/jcm14010268
- 20DOI ↗Effects of combining manual therapies, neck muscle exercises, and therapeutic education pain neuroscience in patients with migraine: a 3-armed randomized clinical trialG. A. Tolentino; L. L. Florencio; J. Pradela; C. F. Pinheiro-Araújo; J. Martins; A. de Cassia Cabral Norato; F. D. Sambini; J. L. Malosti Teodoro Rodrigues; C. Fernández-de-Las-Peñas; F. Dach; D. Bevilaqua-Grossi · Musculoskelet Sci Pract · 2025RCTdoi:10.1016/j.msksp.2025.103360
- 21DOI ↗Pain neuroscience education is not superior to spinal physiology and ergonomics education within a short multidisciplinary rehabilitation program: A randomized controlled trialN. Adenis; V. Wieczorek; S. Corbinau; L. Mortain; A. Thevenon · Musculoskelet Sci Pract · 2024RCTdoi:10.1016/j.msksp.2024.103176
- 22DOI ↗Mediators of pain neuroscience education on disability of patients with nonspecific chronic low back painI. S. Aljulaymi; A. Thackeray; J. M. Fritz; J. S. Magel; P. R. Deboeck; M. A. Qasheesh; F. A. Alodaibi; R. N. Almeheyawi; F. H. Alshehri; H. H. Allam; H. Alzahrani; I. M. Dewir · Fizjoterapia Polska · 2024Otherdoi:10.56984/8ZG020C6WFT
- 23DOI ↗Effects of pain neuroscience education combined with neuromuscular exercises on pain, functional disability and psychological factors in chronic low back pain: A study protocol for a single-blind randomized controlled trialE. Alvani; B. Sheikhi; A. Letafatkar; G. Rossettini · PLoS One · 2024RCTdoi:10.1371/journal.pone.0309679
- 24DOI ↗Pain neuroscience education and graded exposure versus Pilates and postural education: A pilot study in an occupational contextS. M. Alves; E. J. Puentedura; A. G. Silva · Taylor & Francis Ltd · 2024Pilot/feasibilitydoi:10.1080/09593985.2022.2122914
- 25DOI ↗Predictors of improvement in community adolescents with chronic neck pain: A secondary analysis using different improvement criteriaR. Andias; M. Rodrigues; A. G. Silva · Pm r · 2024Otherdoi:10.1002/pmrj.13131
- 26DOI ↗The effects of a prehabilitation programme based on therapeutic exercise, back care education, and pain neuroscience education in patients scheduled for lumbar radiculopathy surgery: A study protocol for a randomised controlled trialM. D. Arguisuelas; M. Garrigós-Pedrón; I. Martínez-Hurtado; J. F. Lisón; G. Biviá-Roig; A. Álvarez-Llanas; E. Tortosa-Sipán; R. Llombart-Blanco; V. Rodrigo-Paradells; M. A. Olmos-García; F. Tomé-Bermejo; J. F. Blanco-Blanco; J. Doménech-Fernández · PLoS One · 2024RCTdoi:10.1371/journal.pone.0303979
- 27DOI ↗Empowering beyond Pain: Pain Neuroscience Education Interventions in Breast Cancer Survivorship CareM. Balordi; P. Tiberio; M. Castaldo; A. Viganò; F. Jacobs; A. Zambelli; A. Santoro; R. De Sanctis · Cancers · 2024Otherdoi:10.3390/cancers16162806
- 28DOI ↗Pain neuroscience education improves post-traumatic stress disorder, disability, and pain self-efficacy in veterans and service members with chronic low back pain: Preliminary results from a randomized controlled trial with 12-month follow-upT. M. Benedict; A. J. Nitz; M. K. Gambrel; A. Louw · Mil Psychol · 2024RCTdoi:10.1080/08995605.2023.2188046
- 29DOI ↗Effectiveness of multimodal active physiotherapy for chronic knee pain: a 12-month randomized controlled trial follow-up studyX. Cui; P. Zhao; X. Guo; J. Wang; T. Han; X. Zhang; X. Zhou; Q. Yan · Front Physiol · 2024RCTdoi:10.3389/fphys.2024.1451345
- 30DOI ↗Effectiveness of pain neuroscience education on somatosensory functioning after surgery for breast cancer: A double-blinded randomized controlled trialL. Dams; E. Van der Gucht; V. Haenen; N. Devoogdt; A. Smeets; K. Bernar; B. Morlion; N. Moloney; S. Fieuws; A. De Groef; M. Meeus · Anat Rec (Hoboken) · 2024RCTdoi:10.1002/ar.25127
- 31DOI ↗A Systematic Review of the Effectiveness of Rehabilitation Programmes or Strategies to Treat People With Persistent Knee Pain Following a Total Knee ReplacementN. Johns; J. M. Naylor; D. McKenzie; B. Brady; B. Thirugnanam; J. Olver · Musculoskeletal Care · 2024Systematic reviewdoi:10.1002/msc.1945
- 32DOI ↗Enhancing pediatric pain management in Turkey: A modified Delphi study on culturally adapted pain neuroscience education for chronic pain in childrenO. K. Kara; C. Gursen; K. Ickmans; E. Rheel; O. Elma; S. Y. Cetin; M. Dogan; M. G. Kutluk; K. Kara · Journal of Pediatric Nursing · 2024Otherdoi:10.1016/j.pedn.2024.09.001
- 33DOI ↗Pain Neuroscience Education Following Arthroscopic Rotator Cuff Repair for Patients With Rotator Cuff Tears: A Double-Blind Randomized Controlled Clinical TrialC. Kararti; F. Özyurt; M. Kodak; H. Basat; G. Özsoy; İ. Özsoy; A. Tayfur · Am J Phys Med Rehabil · 2024RCTdoi:10.1097/phm.0000000000002481
- 34DOI ↗Effects of Manual Therapy Plus Pain Neuroscience Education with Integrated Motivational Interviewing in Individuals with Chronic Non-Specific Low Back Pain: A Randomized Clinical Trial StudyK. Kasimis; T. Apostolou; I. Kallistratos; D. Lytras; P. Iakovidis · Medicina (Kaunas) · 2024RCTdoi:10.3390/medicina60040556
- 35DOI ↗Pain neuroscience education and motor imagery-based exercise protocol for patients with fibromyalgia: A randomized controlled trialS. Kircali; Ö. Özcan; M. Karahan · Brain Behav · 2024RCTdoi:10.1002/brb3.70013
- 36DOI ↗Exercise and Pain Neuroscience Education for Patients With Chronic Pain After Total Knee Arthroplasty: A Randomized Clinical TrialJ. B. Larsen; S. T. Skou; M. Laursen; N. H. Bruun; L. Arendt-Nielsen; P. Madeleine · JAMA Network Open · 2024RCTdoi:10.1001/jamanetworkopen.2024.12179
- 37DOI ↗Effects of Pain Neuroscience Education and Physiotherapy on Chronic Low Back Pain, Fear of Movement and Functional Status: A Randomised Pilot StudyE. Lendraitienė; B. Styraitė; R. Šakalienė; G. Misytė; I. Bileviciute-Ljungar · J Clin Med · 2024RCTdoi:10.3390/jcm13072081
- 38DOI ↗Pain neuroscience education and therapeutic exercise for the treatment of sequelae in breast cancer survivors living with chronic pain: A pilot studyJ. A. Lores-Peniche; G. d. l. Á. Uicab Pool; S. Aguiñaga-Malanco · Journal of Bodywork & Movement Therapies · 2024Pilot/feasibilitydoi:10.1016/j.jbmt.2024.10.025
- 39DOI ↗Pain Neuroscience Education for Acute PainA. Louw; T. Schuemann; K. Zimney; E. J. Puentedura · International Journal of Sports Physical Therapy · 2024Otherdoi:10.26603/001c.118179
- 40DOI ↗A systematic review and meta-analysis of pain neuroscience education for chronic low back pain: short-term outcomes of pain and disabilityX. Ma; R. Chen; W. Li; P. Huang · Physiotherapy Theory & Practice · 2024Meta-analysisdoi:10.1080/09593985.2023.2232003
- 41DOI ↗Cognitive Behavioral Therapy for Insomnia in Pain Management for Nonspecific Chronic Spinal Pain: A Randomized Clinical TrialA. Malfliet; L. De Baets; T. Bilterys; E. Van Looveren; O. Mairesse; B. Cagnie; M. Meeus; M. Moens; D. Goubert; W. Munneke; L. Daneels; K. Ickmans; S. Kamper; J. Nijs · JAMA Network Open · 2024RCTdoi:10.1001/jamanetworkopen.2024.25856
- 42DOI ↗Effectiveness of an interactive online group intervention based on pain neuroscience education and graded exposure to movement in breast cancer survivors with chronic pain: a randomised controlled trialP. Martínez-Miranda; J. J. Jiménez-Rejano; M. J. Muñoz-Fernández; C. García-Muñoz; M. J. Casuso-Holgado · Support Care Cancer · 2024RCTdoi:10.1007/s00520-024-08887-4
- 43DOI ↗A multicenter feasibility randomized controlled trial using a virtual reality application of pain neuroscience education for adults with chronic low back painR. McConnell; E. Lane; G. Webb; D. LaPeze; H. Grillo; J. Fritz · Ann Med · 2024RCTdoi:10.1080/07853890.2024.2311846
- 44DOI ↗Facilitators and barriers to the implementation of pain neuroscience education in the current Lebanese physical therapist health care approach: a qualitative studyC. Najem; A. J. Wijma; M. Meeus; B. Cagnie; F. Ayoubi; J. Van Oosterwijck; K. De Meulemeester; C. P. Van Wilgen · Disability & Rehabilitation · 2024Qualitativedoi:10.1080/09638288.2023.2168076
- 45DOI ↗The optimal dose of pain neuroscience education added to an exercise programme for patients with chronic spinal pain: a systematic review and dose-response meta-analysisR. Núñez-Cortés; J. Salazar-Méndez; J. Calatayud; A. Malfliet; E. Lluch; G. Mendez-Rebolledo; E. Guzmán-Muñoz; R. López-Bueno; L. Suso-Martí · Pain · 2024Meta-analysisdoi:10.1097/j.pain.0000000000003126
- 46DOI ↗Perioperative experiences of patients with high pain catastrophizing and knee arthroplasty after receiving or not preoperative physiotherapy: Qualitative studyM. Ochandorena-Acha; A. Escribà-Salvans; J. A. Hernández-Hermoso; M. Terradas-Monllor · Musculoskelet Sci Pract · 2024Qualitativedoi:10.1016/j.msksp.2024.102918
- 47DOI ↗The effectiveness of telerehabilitation-based exercise combined with pain neuroscience education for patients with facet joint arthrosis: A randomized controlled studyB. Okudan; D. Çelik; O. Koban · Eur J Pain · 2024RCTdoi:10.1002/ejp.2187
- 48DOI ↗Contents and delivery methods of pain neuroscience education in pediatrics: A scoping reviewJ. Rezende; L. Acalantis; L. C. Nogueira; N. Meziat-Filho; K. Ickmans; F. J. J. Reis · Musculoskelet Sci Pract · 2024Systematic reviewdoi:10.1016/j.msksp.2024.103182
- 49DOI ↗Effectiveness of in-group versus individually administered pain neuroscience education on clinical and psychosocial outcomes in patients with chronic low back pain: randomized controlled study protocolJ. Salazar-Méndez; I. Cuyul-Vásquez; F. Ponce-Fuentes; R. Núñez-Cortés; G. Mendez-Rebolledo; J. Fuentes · PeerJ · 2024RCTdoi:10.7717/peerj.17507
- 50DOI ↗Efficacy of preoperative pain neuroscience education in physical therapy on clinical outcomes in patients undergoing arthroplasty: A systematic review of randomized clinical trialsJ. Salazar-Méndez; K. G. Gajardo; M. F. Muñoz-Tapia; C. Sepúlveda-Urrutia; N. Viscay-Sanhueza; G. Mendez-Rebolledo · Journal of Bodywork & Movement Therapies · 2024Systematic reviewdoi:10.1016/j.jbmt.2024.04.007
- 51DOI ↗Effectiveness of an Online Multicomponent Program (FATIGUEWALK) for Chronic Fatigue Syndrome: A Randomized Controlled TrialM. Serrat; J. Navarrete; S. Ferrés; W. Auer; R. Sanmartín-Sentañes; R. Nieto; R. Neblett; X. Borràs; J. V. Luciano; A. Feliu-Soler · Health Psychology · 2024RCTdoi:10.1037/hea0001346
- 52DOI ↗Pain neuroscience education improves quality of life when added to aquatic exercise therapy for women with fibromyalgia: randomized controlled clinical trialA. P. Sousa; L. A. Almeida; B. P. Lourenço; L. D. Alvares; M. A. Avila · Disabil Rehabil · 2024RCTdoi:10.1080/09638288.2023.2201510
- 53DOI ↗Variables associated with nonresponders to high‐frequency (10 kHz) spinal cord stimulationV. Tieppo Francio; J. Alm; L. Leavitt; D. Mok; B. V. Yoon; N. Nazir; C. Lam; U. Latif; T. Sowder; E. Braun; A. Sack; T. Khan; D. Sayed · Pain Practice · 2024Otherdoi:10.1111/papr.13328
- 54DOI ↗Influence of pain neuroscience education and exercises for the management of neck pain: A meta-analysis of randomized controlled trialsY. Zhang; C. Yang · Medicine (Baltimore) · 2024Meta-analysisdoi:10.1097/md.0000000000040760
- 55DOI ↗Supervised exercise therapy versus laser-guided exercise therapy on postural control in subjects with non-specific chronic low back pain: a randomized controlled clinical trialA. Caña-Pino; M. D. Apolo-Arenas; P. Carmona Del Barco; J. Montanero-Fernández; L. Espejo-Antúnez · Eur J Phys Rehabil Med · 2023RCTdoi:10.23736/s1973-9087.23.07430-0
- 56DOI ↗Effect of pain neuroscience education after breast cancer surgery on pain, physical, and emotional functioning: a double-blinded randomized controlled trial (EduCan trial)L. Dams; E. Van der Gucht; N. Devoogdt; A. Smeets; K. Bernar; B. Morlion; L. Godderis; V. Haenen; T. De Vrieze; S. Fieuws; N. Moloney; P. Van Wilgen; M. Meeus; A. De Groef · Pain · 2023RCTdoi:10.1097/j.pain.0000000000002838
- 57DOI ↗Addressing Self-Stigma in Fibromyalgia Using Pain Neuroscience Education: An Occupational Therapy Case StudyC. Davis; M. Gillard · Occupational Therapy in Mental Health · 2023Case seriesdoi:10.1080/0164212X.2022.2149666
- 58DOI ↗Returning to Work After Breast Cancer Surgery: A Randomised Controlled Trial on the Effect of Pain Neuroscience EducationA. De Groef; E. Van der Gucht; N. Devoogdt; A. Smeets; K. Bernar; B. Morlion; L. Godderis; T. De Vrieze; S. Fieuws; M. Meeus; L. Dams · Journal of Occupational Rehabilitation · 2023RCTdoi:10.1007/s10926-023-10103-9
- 59DOI ↗Regional vs global physical therapy interventions to treat chronic pain in survivors of trauma: a randomized controlled trialJ. M. Dee; B. Littenberg · Journal of Manual & Manipulative Therapy (Taylor & Francis Ltd) · 2023RCTdoi:10.1080/10669817.2022.2159615
- 60DOI ↗Pain neuroscience education in persistent painful tendinopathies: A scoping review from the Tendon PNE NetworkA. Escriche-Escuder; J. Nijs; K. G. Silbernagel; C. P. van Wilgen; M. L. Plinsinga; J. Casaña; A. I. Cuesta-Vargas · Phys Ther Sport · 2023Systematic reviewdoi:10.1016/j.ptsp.2023.07.002
- 61DOI ↗The effectiveness of low-dosed outpatient biopsychosocial interventions compared to active physical interventions on pain and disability in adults with nonspecific chronic low back pain: A systematic review with meta-analysisM. Hochheim; P. Ramm; V. Amelung · Pain Pract · 2023Meta-analysisdoi:10.1111/papr.13198
- 62DOI ↗Musculoskeletal dysfunctions and physiotherapy treatment strategies in patients with migraineK. Luedtke; G. Carvalho; T. Szikszay · Musculoskelet Sci Pract · 2023Otherdoi:10.1016/j.msksp.2023.102805
- 63DOI ↗Is it Possible to Reduce Pain-Related Fear in Individuals with Knee Osteoarthritis? a Systematic Review of Randomised Clinical TrialsJ. Martinez-Calderon; M. Flores-Cortes; J. M. Morales-Asencio; C. Pineda-Galán; M. C. García-Rios; M. Torrontegui-Duarte; A. Luque-Suarez · Physiotherapy Theory & Practice · 2023Systematic reviewdoi:10.1080/09593985.2022.2038743
- 64DOI ↗Additional effects of pain neuroscience education combined with physiotherapy on the headache frequency of adult patients with migraine: A randomized controlled trialR. Meise; G. F. Carvalho; C. Thiel; K. Luedtke · Cephalalgia · 2023RCTdoi:10.1177/03331024221144781
- 65DOI ↗Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary careC. Murillo; M. Galán-Martín; F. Montero-Cuadrado; E. Lluch; M. Meeus; W. W. Loh · Pain · 2023RCTdoi:10.1097/j.pain.0000000000002929
- 66DOI ↗Effectiveness of adding pain neuroscience education to telerehabilitation in patients with carpal tunnel syndrome: A randomized controlled trialR. Núñez-Cortés; C. Cruz-Montecinos; S. Torreblanca-Vargas; C. Tapia; M. Gutiérrez-Jiménez; P. Torres-Gangas; J. Calatayud; S. Pérez-Alenda · Musculoskelet Sci Pract · 2023RCTdoi:10.1016/j.msksp.2023.102835
- 67DOI ↗Management of chronic musculoskeletal pain in an adult with Down syndrome using a modified pain neuroscience approach: a case reportM. Osborne; J. K. Grimes · Physiotherapy Theory & Practice · 2023Case seriesdoi:10.1080/09593985.2022.2095682
- 68DOI ↗The effect of implementation of pain neuroscience education and rehabilitation exercise on post-operative pain and recovery after laparoscopic colorectal surgery: a prospective randomized controlled trialL. Peng; Y. Song; B. Lv; C. Jing · J Anesth · 2023RCTdoi:10.1007/s00540-023-03235-y
- 69DOI ↗Effects of pain neuroscience education and rehabilitation following arthroscopic rotator cuff repair. A randomized clinical trialF. Ponce-Fuentes; I. Cuyul-Vásquez; L. Bustos-Medina; J. Fuentes · Taylor & Francis Ltd · 2023RCTdoi:10.1080/09593985.2022.2061394
- 70DOI ↗Remotely Delivered Psychologically Informed Mindful Movement Physical Therapy for Pain Care: A Framework for OperationalizationM. B. Sullivan; K. Hill; L. A. Ballengee; D. Knoblach; C. Fowler; J. Haun; M. Saenger · Global Advances in Integrative Medicine & Health · 2023Otherdoi:10.1177/27536130231209751
- 71DOI ↗Effect of Pain Neuroscience Education with Conventional Physiotherapy via Telerehabilitation on Pain Catastrophizing and Function in Patients with Osteoarthritis Knee: A Randomized Controlled TrialH. M. Supe; S. S. Mungikar; G. A. Katage; K. A. Garg; S. K. Wani · J Midlife Health · 2023RCTdoi:10.4103/jmh.jmh_33_23
- 72DOI ↗Additional effect of pain neuroscience education to spinal manipulative therapy on pain and disability for patients with chronic low back pain: a randomized controlled trialF. A. G. Tavares; J. V. A. Rossiter; G. C. L. Lima; L. G. de Oliveira; W. S. Cavalcante; M. A. Ávila; S. Z. George; T. C. Chaves · Brazilian Journal of Physical Therapy · 2023RCTdoi:10.1016/j.bjpt.2023.100555
- 73DOI ↗A feasibility study of home-based preoperative multimodal physiotherapy for patients scheduled for a total knee arthroplasty who catastrophize about their painM. Terradas-Monllor; M. Ochandorena-Acha; H. Beltran-Alacreu; E. Garcia Oltra; F. Collado Saenz; J. Hernandez Hermoso · Taylor & Francis Ltd · 2023Pilot/feasibilitydoi:10.1080/09593985.2022.2044423
- 74DOI ↗Prehabilitation before total knee arthroplasty: A systematic review on the use and efficacy of stratified careS. Vervullens; L. Meert; I. Baert; R. Smeets; P. Verdonk; F. Rahusen; M. Meeus · Ann Phys Rehabil Med · 2023Systematic reviewdoi:10.1016/j.rehab.2022.101705
- 75DOI ↗Physiotherapeutic treatment associated with the pain neuroscience education for patients with chronic non-specific low back pain-single-blind randomized pilot clinical trialA. S. Yamada; F. T. T. Antunes; S. M. R. Vaz; B. V. Saraiva; A. H. De Souza; D. Simon · Agri · 2023RCTdoi:10.14744/agri.2022.33349
- 76DOI ↗Blended-Learning Pain Neuroscience Education and Exercise in High School Students With Chronic Neck Pain: A Randomized Controlled TrialR. Andias; P. Sa-Couto; A. G. Silva · PTJ: Physical Therapy & Rehabilitation Journal · 2022RCTdoi:10.1093/ptj/pzac048
- 77DOI ↗Effectiveness of a group intervention using pain neuroscience education and exercise in women with fibromyalgia: a pragmatic controlled study in primary careP. B. Areso-Bóveda; J. Mambrillas-Varela; B. García-Gómez; J. I. Moscosio-Cuevas; J. González-Lama; E. Arnaiz-Rodríguez; M. B. A. del Barco; P. S. Teodoro-Blanco · BMC Musculoskeletal Disorders · 2022Otherdoi:10.1186/s12891-022-05284-y
- 78DOI ↗Effect of pain neuroscience education and transcutaneous electrical nerve stimulation on trigeminal postherpetic neuralgia. A case reportM. Barone; F. Imaz; D. Bordachar; I. Ferreira; L. Intelangelo · Physiother Theory Pract · 2022Case seriesdoi:10.1080/09593985.2021.1878567
- 79DOI ↗Influence of education level on the effectiveness of pain neuroscience education: A secondary analysis of a randomized controlled trialT. Bilterys; J. Kregel; J. Nijs; M. Meeus; L. Danneels; B. Cagnie; E. Van Looveren; A. Malfliet · Musculoskelet Sci Pract · 2022RCTdoi:10.1016/j.msksp.2021.102494
- 80DOI ↗Pain Science Education Plus Exercise Therapy in Chronic Nonspecific Spinal Pain: A Systematic Review and Meta-analyses of Randomized Clinical TrialsL. Bonatesta; J. D. Ruiz-Cárdenas; L. Fernández-Azorín; J. J. Rodríguez-Juan · J Pain · 2022Meta-analysisdoi:10.1016/j.jpain.2021.09.006
- 81DOI ↗Language Discordance and Telephone Interpretation Complicates Pain Neuroscience Education in Physical Therapy Management of a Patient with Acute Low Back PainM. C. Burns; T. S. Struessel · Internet Journal of Allied Health Sciences & Practice · 2022OtherPMID 154640281
- 82DOI ↗Pain Neuroscience Education and Motor Control Exercises versus Core Stability Exercises on Pain, Disability, and Balance in Women with Chronic Low Back PainS. M. Gorji; H. Mohammadi Nia Samakosh; P. Watt; P. Henrique Marchetti; R. Oliveira · Int J Environ Res Public Health · 2022Otherdoi:10.3390/ijerph19052694
- 83DOI ↗The Efficacy of Pain Neuroscience Education on Active Rehabilitation Following Arthroscopic Rotator Cuff Repair: A CONSORT-Compliant Prospective Randomized Single-Blind Controlled TrialH. Kim; S. Lee · Brain Sci · 2022RCTdoi:10.3390/brainsci12060764
- 84DOI ↗Effectiveness of training physical therapists in pain neuroscience education for patients with chronic spine pain: a cluster-randomized trialE. Lane; J. S. Magel; A. Thackeray; T. Greene; N. F. Fino; E. J. Puentedura; A. Louw; D. Maddox; J. M. Fritz · PAIN · 2022RCTdoi:10.1097/j.pain.0000000000002436
- 85DOI ↗Pilot study on the effects of a culturally-sensitive and standard pain neuroscience education for Hausa-speaking patients with chronic neck painN. B. Mukhtar; M. Meeus; C. Gursen; J. Mohammed; R. De Pauw; B. Cagnie · Disability & Rehabilitation · 2022Pilot/feasibilitydoi:10.1080/09638288.2021.1988155
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- 87DOI ↗Exercise physiologists use of pain neuroscience education for treating knee osteoarthritis: A qualitative interview studyA. Ram; J. Booth; J. M. Thom; M. D. Jones · Musculoskeletal Care · 2022Qualitativedoi:10.1002/msc.1631
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- 89DOI ↗Effectiveness of two video-based multicomponent treatments for fibromyalgia: The added value of cognitive restructuring and mindfulness in a three-arm randomised controlled trialM. Serrat; K. Albajes; J. Navarrete; M. Almirall; E. Lluch Girbés; R. Neblett; J. V. Luciano; J. Moix; A. Feliu-Soler · Behav Res Ther · 2022RCTdoi:10.1016/j.brat.2022.104188
- 90DOI ↗Short-term impact of combining pain neuroscience education with exercise for chronic musculoskeletal pain: a systematic review and meta-analysisB. Siddall; A. Ram; M. D. Jones; J. Booth; D. Perriman; S. J. Summers · PAIN · 2022Meta-analysisdoi:10.1097/j.pain.0000000000002308
- 91DOI ↗Group pain neuroscience education and dance in institutionalized older adults with chronic pain: a case series studyP. Simões; R. Andias; D. Simões; A. G. Silva · Taylor & Francis Ltd · 2022Case seriesdoi:10.1080/09593985.2020.1728794
- 92DOI ↗Impact of Pain Neuroscience Education Program in Community Physiotherapy Context on Pain Perception and Psychosocial Variables Associated with It in Elderly Persons: A Ranzomized Controlled TrialJ. Vicente-Mampel; P. Gargallo; I. J. Bautista; P. Blanco-Gímenez; N. de Bernardo Tejedor; M. Alonso-Martín; M. Martínez-Soler; L. Baraja-Vegas · Int J Environ Res Public Health · 2022Otherdoi:10.3390/ijerph191911855
- 93DOI ↗Does combined individualized orofacial manual therapy, pain neuroscience education, and brain training change orofacial pain, chronic face dysfunction, (facial) body perception and pain? An observational mixed methods case series studyH. Von Piekartz; G. Geitner; D. Möller; R. Braun; T. Hall · Journal of Manual & Manipulative Therapy (Taylor & Francis Ltd) · 2022Case seriesdoi:10.1080/10669817.2021.2018102
- 94DOI ↗Client buy-in: An essential consideration for graded motor imagery in hand therapyP. Bakshi; W.-P. Chang; T. F. Fisher; B. Andreae · Journal of Hand Therapy · 2021Otherdoi:10.1016/j.jht.2020.03.014
- 95DOI ↗Influence of Baseline Kinesiophobia Levels on Treatment Outcome in People With Chronic Spinal PainW. V. Bogaert; I. Coppieters; J. Kregel; J. Nijs; R. D. Pauw; M. Meeus; B. Cagnie; L. Danneels; A. Malfliet · PTJ: Physical Therapy & Rehabilitation Journal · 2021Otherdoi:10.1093/ptj/pzab076
- 96DOI ↗Do Sex and Pain Characteristics Influence the Effectiveness of Pain Neuroscience Education in People Scheduled for Total Knee Arthroplasty? Secondary Analysis of a Randomized Controlled TrialE. Huysmans; J.-P. Baeyens; L. Dueñas; D. Falla; M. Meeus; E. Roose; J. Nijs; E. Lluch Girbés · PTJ: Physical Therapy & Rehabilitation Journal · 2021RCTdoi:10.1093/ptj/pzab197
- 97DOI ↗Effect of pain neuroscience education and exercise on presenteeism and pain intensity in health care workers: A randomized controlled trialR. Imai; T. Konishi; A. Mibu; K. Tanaka; T. Nishigami · J Occup Health · 2021RCTdoi:10.1002/1348-9585.12277
- 98DOI ↗Pain Neuroscience Education Combined with Therapeutic Exercises Provides Added Benefit in the Treatment of Chronic Neck PainN. Javdaneh; A. H. Saeterbakken; A. Shams; A. H. Barati · Int J Environ Res Public Health · 2021Otherdoi:10.3390/ijerph18168848
- 99DOI ↗Embedding pain neuroscience education in the physical therapy management of patients with chronic plantar fasciitis: a prospective case seriesK. M. Mills; E. B. Preston; B. M. Choffin Schmitt; H. K. Brochu; E. A. Schafer; P. E. Robinette; E. K. Sterling; R. A. Coronado · Journal of Manual & Manipulative Therapy (Taylor & Francis Ltd) · 2021Cohort studydoi:10.1080/10669817.2020.1821327
- 100DOI ↗Culture-sensitive and standard pain neuroscience education improves pain, disability, and pain cognitions in first-generation Turkish migrants with chronic low back pain: a pilot randomized controlled trialC. Orhan; D. Lenoir; A. Favoreel; E. Van Looveren; V. Yildiz Kabak; N. B. Mukhtar; B. Cagnie; M. Meeus · Taylor & Francis Ltd · 2021RCTdoi:10.1080/09593985.2019.1639231
- 101DOI ↗Comparing Pain Neuroscience Education Followed by Motor Control Exercises With Group-Based Exercises for Chronic Low Back Pain: A Randomized Controlled TrialP. Rabiei; B. Sheikhi; A. Letafatkar · Pain Pract · 2021RCTdoi:10.1111/papr.12963
- 102DOI ↗Pain neuroscience education combined with usual treatment for fibromyalgia syndrome: A randomized controlled trialI. Saracoglu; M. A. Leblebicier; F. Yaman; V. Kavuncu · Int J Rheum Dis · 2021RCTdoi:10.1111/1756-185x.14223
- 103DOI ↗Effectiveness of a Multicomponent Treatment Based on Pain Neuroscience Education, Therapeutic Exercise, Cognitive Behavioral Therapy, and Mindfulness in Patients With Fibromyalgia (FIBROWALK Study): A Randomized Controlled TrialM. Serrat; J. P. Sanabria-Mazo; M. Almirall; M. Musté; A. Feliu-Soler; J. L. Méndez-Ulrich; A. Sanz; J. V. Luciano · PTJ: Physical Therapy & Rehabilitation Journal · 2021RCTdoi:10.1093/ptj/pzab200
- 104DOI ↗How manual therapy provided a gateway to a biopsychosocial management approach in an adult with chronic post-surgical low back pain: a case reportD. Toomey; D. Reid; S. White · Journal of Manual & Manipulative Therapy (Taylor & Francis Ltd) · 2021Case seriesdoi:10.1080/10669817.2020.1813472
- 105DOI ↗Effects of pain neuroscience education and dry needling for the management of patients with chronic myofascial neck pain: a randomized clinical trialP. Valiente-Castrillo; A. Martín-Pintado-Zugasti; C. Calvo-Lobo; H. Beltran-Alacreu; J. Fernández-Carnero · Acupuncture in Medicine · 2021RCTdoi:10.1177/0964528420920300
- 106DOI ↗Exercise and education for knee osteoarthritis—What are accredited exercise physiologists providing?A. Ram; J. Booth; J. Thom; M. D. Jones · Musculoskeletal Care · 2020Otherdoi:10.1002/msc.1477
- 107DOI ↗Investigating the effects of myofascial induction therapy techniques on pain, function and quality of life in patients with chronic low back painM. Ünal; E. Evci̇k; M. Kocatürk; Z. C. Algun · Journal of Bodywork & Movement Therapies · 2020Otherdoi:10.1016/j.jbmt.2020.07.014
- 108DOI ↗The moderating effects of pain catastrophizing on the relationship between illness perceptions and self-reported signs of central sensitization in patients with persistent painA. J. Wijma; R. Bults; J. Nijs; C. Paul van Wilgen · International Journal of Rehabilitation Research · 2020Otherdoi:10.1097/MRR.0000000000000433